Expression of Mucins, SIMA, Villin, and CDX2 in Small-Intestinal Adenocarcinoma
نویسندگان
چکیده
منابع مشابه
Expression of CDX2 and villin in gastric cardiac intestinal metaplasia and the relation with gastric cardiac carcinogenesis.
OBJECTIVE To determine whether CDX2 and villin protein expression are associated with intestinal metaplasia (IM) in gastric cardiac mucosa and to explore the relationship with evolution of gastric cardiac adenocarcinoma (GCA). METHODS We studied 143 gastric cardiac biopsy or resection specimens from Henan province China, including 25 cardiac gastritis specimens with IM, 65 dysplasia specimens...
متن کاملCDX2 and villin are useful markers of intestinal metaplasia in the diagnosis of Barrett esophagus.
The identification of intestinal metaplasia (IM) in the esophagus is necessary for the selection of patients with Barrett esophagus (BE) for surveillance. We studied 108 esophageal biopsy and resection specimens, clinically diagnosed as BE, and stained them for CDX2, villin, HepPar-1, and cytokeratin (CK) 7 to investigate sensitivity for identifying IM. H&E-stained sections showed definite gobl...
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BACKGROUND Intestinal-type sinonasal adenocarcinoma (ITAC) is an uncommon neoplasm, which resembles adenocarcinoma of the gastrointestinal tract. ITAC occurs sporadically or in association with occupational exposure to hardwood dust and other agents. AIMS To investigate the phenotype and possible pathogenetic mechanisms of primary sinonasal and nasopharyngeal adenocarcinomas by staining for c...
متن کاملExpression of hepatocyte antigen in small intestinal epithelium and adenocarcinoma.
Hepatocyte antigen is recognized by antibody Hep Par 1, a widely used diagnostic immunomarker for hepatocellular carcinoma and tumors with hepatoid differentiation. Hepatocyte antigen expression has also been detected in nonneoplastic small intestinal epithelium, but expression in small intestinal adenocarcinoma has not been well investigated. We immunohistochemically examined 39 nonampullary s...
متن کاملExpression of homeodomain protein CDX2 in colorectal adenoma and adenocarcinoma.
CDX2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestine. In this study, we examined CDX2 expression in normal and neoplastic human colon using a newly isolated monoclonal antibody. When compared to the intensity observed in adjacent normal mucosal epithelial cells, strong nuclear staining for CDX2 was observed in 10 (10...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2007
ISSN: 0002-9173,1943-7722
DOI: 10.1309/jaf3kvgjhqcj1qf9